#13 Ico
Ico is a game about a boy who rescues a girl with whom he must escort out of a strange castle. Haunted by shadowy apparitions who threaten to kidnap the girl, the boy (and thus the player) must use his wits to keep the girl safe while traversing through treacherous territory.
The boy's relationship with the girl becomes an integral key to most of the puzzles, and forces the player to consider the girl in every level of the game.