• Skip to main content
  • Skip to header right navigation
  • Skip to site footer
Gameranx

Gameranx

Video Game News, Lists & Guides

  • News
  • Features
  • Platforms
    • Xbox Series X
    • PS5
    • Nintendo
  • Videos
  • Upcoming Games
  • Guides
  • News
  • Features
  • Platforms
    • Xbox Series X
    • PS5
    • Nintendo
  • Videos
  • Upcoming Games
  • Guides

Dead Cells: How To Get The Homunculus Rune & A Secret Spawn Blueprint | Disengagement Guide

August 21, 2018 by Kevin Thielenhaus

See how to get one of the trickiest secret blueprints in Dead Cells with this quick guide, explaining where to get the Disengagement Mutation, and which runes you’ll need.

The secret blueprint is in an alcove all the way up top in the spawn room.

There’s one final rune you can unlock in Dead Cells, and getting it gives you access to a super secret blueprint in the spawn room. The Homunculus Rune is unlocked in a pretty straightforward way — you just need to defeat the Hand of the King and complete the game. This gives you the ability to detach your head and crawl around freely. Your head-plant-thing can crawl through tiny passages that your full-body can’t squeeze through.

And even knowing that much doesn’t really help you get the useful Disengagement Mutation blueprint. It’s one of the last secrets you’ll find right at the start, and it’s totally impossible to collect until you’ve earn the Homunculus Rune.

Learn how to get the Disengagement Mutation Blueprint in the quick guide below, along with a few more details on the sometimes-powerful Homunculus Rune.


More Dead Cells guides on Gameranx:

  • Dead Cells: 10 Tips To Help You Beat The Game | Completion Guide
  • Dead Cells: How To Find Keys & Cash In The Promenade | Secrets Guide
  • Dead Cells: How To Get The Vine, Teleportation, Ram & Spider Runes | Locations Guide
  • Dead Cells: Want To Make Easy Progress? Equip Double Turrets | Powerful Build Guide
  • Dead Cells: How To Access Every Area | Hidden & Optional Areas Guide
  • Dead Cells: All Secret Key & Blueprint Locations | Gardener’s Keys, Architect’s Key & More
  • Dead Cells: How To Beat The Hand Of The King | Last Boss Guide

How To Get The Homunculus Rune & A Secret Spawn Blueprint | Disengagement Guide
Dead Cells_20180820215233
Dead Cells_20180820215238
Dead Cells_20180820215245
Dead Cells_20180820215310
Dead Cells_20180820215523
Dead Cells_20180820215527
Dead Cells_20180820220027

 

The Homunculus Rune is unlocked when you defeat the Hand of the King, then kill the king himself. Once the credits roll, you’ll respawn in the starting room as if nothing happened — but, you’ll gain a Stem Cell (or Boss Cell) that you can use to go up one difficulty level.

  • Homunculus Rune: Unlocked after completing the game once. Press [R3 / V] to launch your head. It can stick to walls, crawl through narrow spaces, and stuns enemies it attaches to. You can move freely even with the head detached and continue to attack after it latches onto an enemy. The head is attached by a vine, and it will return to your body if the vine is stretched too far.

The Homunculus Rune isn’t just a useful tool for fighting enemies. You can also use it to access previously unreachable secret areas — including the Disengagement Mutation Blueprint. To unlock this secret blueprint, follow the steps below.

  • Disengagement Mutation Blueprint:
    1. Restart from the spawn room and stick to the left wall (Spider Rune required), then jump to the right wall. If you stick to the right wall, you’ll be able to see the Disengagement Rune in a hidden alcove.
    2. To reach it, launch your Homunculus Rune head into the wall just as you jump. While you’re stuck to the right wall, you’ll have just enough time to navigate the secret passage with your head. When your body slips off the wall and falls, the vine tether will pull the head back to the body.
    3. Mid-jump, launch your head into the wall then hold down-right until you enter the secret tunnel. Go right, then up, then right, and down to reach the blueprint.

If you can stick the vine-head into the blueprint alcove before your body falls to the ground, you’ll be able to bring the item back. Tap [R3 / V] to re-summon your head, and you’ll collect the blueprint. It’s just that simple, but only eagle-eyed players will ever even spot this thing.

The Disengagement Rune gives you a 6 second invincibility shield after your health drops below 20% — this is insanely useful. You can use that invulnerability time to attack opponents or just heal from a position of total safety. It’s really good, especially for high-difficulty runs.

Share this post:

FacebookTwitterLinkedInPinterest

Recent Videos

10 Games That RUINED Single Player Games For Us

10 Games That RUINED Single Player Games For Us

20 LEGENDARY Games Worth Revisiting in 2025

20 LEGENDARY Games Worth Revisiting in 2025

CHEATER FINED $175000, RED DEAD ONLINE RETURNS? & MORE

CHEATER FINED $175000, RED DEAD ONLINE RETURNS? & MORE

What The HELL is GOING on With Xbox?

What The HELL is GOING on With Xbox?

10 LOCKED Areas Developers Didn't Think WE'D UNLOCK

10 LOCKED Areas Developers Didn't Think WE'D UNLOCK

Top 25 NEW Games of 2025 [Second Half]

Top 25 NEW Games of 2025 [Second Half]

10 WEIRD Gaming Stories of June 2025

10 WEIRD Gaming Stories of June 2025

10 1000 IQ Moments in Video Games That Are GENIUS

10 1000 IQ Moments in Video Games That Are GENIUS

25 Best Isometric RPGs That DEFINED A GENERATION

25 Best Isometric RPGs That DEFINED A GENERATION

Category: FeaturesTag: Dead Cells, Guides, PC, PS4, Xbox One

Sidebar

Recent Posts

  • Pokémon Go: Hisuian Lilligant Raid Day Schedule and Bonuses
  • Death Stranding 2: How To Find Mr. Impossible’s Cargo | Secret Locations
  • Splitgate 2: How to Play Ranked
  • Best New Games of June 2025
  • Roblox The Hatch Egg Collecting Guide

Copyright © 2025 · Gameranx · All Rights Reserved · Powered by Mai Theme