#5 Deus ex: Human Revolution
Human Revolution is primarily a first person shooter with strong RPG elements that, if it's anything like the first two games, will allow you to approach combat situations based on your own personal preference. You can take out enemy combatants through stealth, brute force, or even use your hacking abilities to get sentry guns and armed robots to do your bidding for you.
Taking a cue from Ghost in the Shell, Deus Ex carries a strong cyberpunk motif. If things continue to head in the direction they're heading in the real world, there's little doubt that we'll be living in a world just like the one depicted by these games.