Rock Band Blitz isn't a traditional Rock Band game, and that's not a bad thing. While some people don't get the idea of a Harmonix game that doesn't use plastic instruments, others are excited for a chance to renew their skills honed in games like Amplitude and Frequency. Either way, it doesn't matter what your preference is, buy Rock Band Blitz is a must for fans of the series, if only for the free export of new tracks.
Further creating a distance between the two different Rock Band styles is the use of power-ups in Blitz. As you can see in the video above, things can be a little bit over the top, but ultimately the idea is that you maximise your points in fun and entertaining ways. How on earth that'll affect the leader boards I don't know, but I'm willing to reserve judgement.
Rock Band Blitz is still due in "Summer 2012," but expect more announcements during E3.