Alien Isolation lead designer Gary Napper has told AvPGalaxy that the possibility of a sequel is discussed regularly at developer The Creative Assembly.
The game takes places 15 years after the events of the original Alien movie and features franchise heroine Ellen Ripley's daughter Amanda
"The plot for a sequel is a daily topic in the studio sometimes," Napper commented. "People have their own ideas for where it should go, our writers have some solid concepts and yes, we do have a great opportunity to continue her story. I personally think that Amanda did not get infected in the hive, as when she wakes, the closest egg remains closed.
"If we made a sequel," he added, "I would like to stick to the same terrifying single Alien approach but do more with the environment and interactivity within it."
You can check out our 8.5/10 review of Alien Isolation here.