10. Beyond Good & Evil 2 Announcement
While we may know that Beyond Good & Evil 2 is currently in development at Ubisoft, the chances that it'll be announced at this year's E3 are unlikely given the stage of development it's currently in and the fact that announcing it might well eclipse anything else they have to show.
Notably, Ubisoft is counting on Assassin's Creed III to be the talk of the show this year, and bringing up BG&E2 could put a slight damper on that. That said, surprises have been known to happen at E3 so we won't rule it out from happening completely. It's just very unlikely, is all.
If anything, the game is likely slated for release on the next generation of consoles, and not the current ones.
