1. New England during the American Revolution
Why it'd be awesome:
Hey, just because it's popular doesn't mean it's not a great idea. The American Revolution is bursting with iconic events and personalities that perfectly fit the Assassin's Creed mold. With a little imagination, the game practically writes itself. Ben Franklin is the quirky inventor who supplies you with new gadgets. Sam Adams, Thomas Jefferson and the other patriots are actually a secret society of Assassins working to foil some Templar scheme. It'd be like Assassin's Creed meets National Treasure, only with less Nic Cage. Everybody wins!
Why it could happen:
With a few important cities — New York, Boston, and Philadelphia — and a lot of countryside in between, the American Revolution certainly lends itself to the typical Assassin's Creed experience, at least from a geographical standpoint. The conflict's "liberty versus tyranny" theme also dovetails nicely with the series' central conflict between the Assassins and Templars.
The end of Revelations also contains references to an important location in upstate New York, making this the perfect setting to wrap up Desmond's story arc.
Why it might not:
The smart money's here, and for good reason. There aren't many downsides to setting the game during the American Revolution, save for the fact that it might alienate fans in countries that don't place as much emphasis on the period as the US does.