2. British Colonial India
Why it'd be awesome:
Four games in, the Assassin's Creed franchise is starting to feel a tad bit formulaic. A shift to a more exotic setting would definitely help fix that, and the tropical climes of India seem like a great bet. Any one of half a dozen cities would provide unique architecture, a drastically different culture and mythology to delve into, and — most importantly — the chance to assassinate someone while they're riding an elephant.
Why it could happen:
If there's one glaring theme that runs throughout every one of Assassin's Creed's settings, it's the sense that you're at a cultural crossroads. Old architecture meets new, Western influence meets Eastern, and the result is always a rich, varied world for you to traverse. Colonial India would have that in spades, with ancient buildings standing alongside newer, more European designs, and the tension of imperialism looming ever large in the background.
Why it might not:
While the broader strokes match up well, it's hard to imagine the specifics panning out. The Assassin's Creed franchise tends to focus on brief, tumultuous eras that had a lasting impact on the world. The Indian independence movement was a very gradual, protracted process, and it didn't result in any remarkable shifts in the geopolitical climate. Besides, we're fairly certain Ghandi's philosophy of passive resistance wouldn't mesh too well with the Assassins' violent way of life.