#3 BioShock Infinite
How in the world do you follow up on a game as revolutionary as BioShock? The answer, according to Irrational Games, is to change everything. No more Big Daddies, no more Little Sisters, no more Rapture. In fact, BioShock Infinite's story takes place before the first game and appears to be completely unrelated, centered instead upon flying city of Columbia.
While the first game's combat mechanics — a blend of gunplay and superpowered abilities — are more or less intact, they're now just the base for something much more complex. You've now got two more crucial tools at your disposal, the skyhook, which lets you grapple onto railways to move rapidly during a battle, and Elizabeth, whose mysterious powers allow her to manipulate the world around her. Thrown in some stellar writing and a radical new AI system, and you've got more than a few reasons to be excited.