#5 Mass Effect 3
Whether you opt for male Shepard, FemShep, or something else entirely, he/she/it is one of the most memorable protagonists in gaming history, made all the better by the fact that you can decide the outcome of their story. In Mass Effect 3, that adventure will finally come to its close. That means no more cliffhangers or stalling, just an action-packed conclusion to one of the best sci-fi epics ever to grace the medium.
And if saving the galaxy from a Reaper invasion isn't enough to whet your appetite, there's also the promise of a horde-style co-op mode. With support for up to four players, persistent character leveling, and a chance to impact the outcome of the single-player campaign, multiplayer should prove an interesting addition to the franchise, at least for the laughs you'll getting sending your friends flying with your biotic powers.