Sanctuary (Borderlands 2)
Sanctuary gives access to a bank, shared stash, and all the NPCs and vending machines you could ever need in your vault hunting adventures. It's also the central location for your merry band of rebels and features prominently in the story.
Having your only friendly place on Pandora teleport across the world is a shocking moment mid-game, and nothing says motivation than wanting to get all your stuff back.
