#5 Tiny Tina
Another uncharacteristic addition to the list, Tiny Tina of Borderlands 2 fame first comes across as a crazy little girl. Eventually it’s rather clear that there’s a lot more to her than meets the eye, first being real mental problems brought about by the brutal loss of her parents, and later of her friends. The game explores these coloured grey areas of her life in a funny tactful way, but the subtext is still there, all the more present in the expansion Tiny Tina's Assault on Dragon Keep.
It works in a way that makes her quirky and fun, but also complex. Kudos to Anthony Burch and his sister Ashly for bringing this character into reality.