Speaking to GamesRadar Insomniac Games' President Ted Price revealed that the studio "seriously considered" developing Resistance 4.
However, the studio's plans changed in a bid to avoid "series fatigue" with Resistance 3 being seen as a logical conclusion to the series.
"We decided to bring Resistance to a conclusion when we looked ahead and realised that Resistance 4, while possible and something we seriously considered, wasn't going to be the right game for us at that time," Price commented, adding "We wanted to do something new.
"One of the aspects of building franchises, and sticking with them for a long time is that even the team can get franchise fatigue. We had been pushing hard with Resistance from the beginning – which was a tough birth – to Resistance 3, which is a game we were all very proud of.
"With Resistance 3 it felt like we had capped off, or at least closed a major chapter in that franchise. So, a lot of the the team was looking forward to doing something different."
That 'something different' is Fuse, a co-op title, which is set to be released on PS3 and Xbox 360 on May 28th. Aside from the core Resistance games on PS3 Resistance: Retribution and Resistance: Burning Skies have been released for PSP and PS Vita respectively.
It's unclear what, if anything, Sony plans to do with the franchise which they own the rights to.