1. Uncharted: Golden Abyss
Other games may do a better job of showcasing the Vita's new control mechanics but the Vita's real potential doesn't lie in waggle or touchscreens, it's in the ability to deliver console-caliber experiences on the go. Golden Abyss does that in a big way.
If you look past the forced gimmicks and shy away from the annoyingly oversimplified touchscreen climbing mechanics, you'll find a brand new experience that's just as good as the rest of the Uncharted canon. The only thing that's really lacking is multiplayer, but I suppose that's something for the inevitable sequel to tackle.
